The Bid & Ask

Quotations, Dispatches, and the Daily Tape

Thursday, August 13, 2026

Subject of the day

PTGX

Concerning the House

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

United States · www.protagonist-inc.com

The Long Run

FY 2016–2025 · 10 years

LineLatestCAGRTrend
Operating income-$158.13M
Net income-$130.15M
Cash from ops$57.67M
Quotation

$151.42

-0.59 (-0.4%)

52w hi$152.01
52w lo$54.53
Vol378.98K
As ofAug 13
The Verdict

Hold

Our score +0.17

Short-0.12
Medium+0.28
Long+0.52

computed 2026-08-13

By the Numbers

Protagonist Therapeutics, Inc.

Healthcare · Biotechnology

Market cap$9.80B
Enterprise value$9.06B
Trailing P/E147.01x
Forward P/E-1082.96x
EV / EBITDA151.34x
P / S (ttm)34.75x
Profit margin29.4%
Return on equity11.0%
Revenue growth+3749.2%
Earnings growth
Debt / equity1.09
Risk Metrics
Beta vs SPX0.25
Corr SPX0.07
Annual vol57.0%
Annual ret+85.6%
Sharpe1.50
Max DD-31.6%

Window: 504 trading days (504 obs)

Layer Breakdown
LayerRawContribution
Fundamental+0.34
Sector+0.12
Technical+0.00
Earnings+0.00
Sentiment+0.00

macro × 1.00 · 2026-08-13

Recent Sessions
DateOpenHighLowCloseVol
Aug 13$153.15$154.99$150.92$151.42378.98K
Aug 12$148.21$152.70$147.33$152.01417.20K
Aug 11$151.88$151.88$147.37306.10K
Aug 10$149.31$151.60$147.40$150.00545.80K
Aug 7$146.18$147.32$144.44$145.87321.10K