Inside the research

Protagonist Therapeutics, Inc.

PTGX Research profile · latest available data

Price overview

$141.86

▲ +4.52 (+3.3%)

52w hi$158.62
52w lo$64.00
Vol809.20K
As of25 Sep 2026

The Verdict

Buy

Our score +0.66

Short+0.59
Medium+0.75
Long+0.64

computed 2026-09-27

Key fundamentals

Protagonist Therapeutics, Inc.

Healthcare · Biotechnology

Market cap$9.18B
Enterprise value$8.41B
Trailing P/E136.40x
Forward P/E-712.33x
EV / EBITDA140.38x
P / S (ttm)32.55x
Profit margin29.4%
Return on equity11.0%
Revenue growth+3749.2%
Debt / equity1.09

Layer Breakdown

LayerRawContribution
Fundamental+0.34
Sector+0.08
Technical+0.34
Earnings+0.00
Sentiment+0.22

macro × 1.00 · 2026-09-27

Business overview

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

United States · www.protagonist-inc.com

Risk Metrics

Beta vs SPX0.22
Corr SPX0.06
Annual vol56.8%
Annual ret+69.4%
Sharpe1.22
Max DD-31.6%

Window: 504 trading days (504 obs)

Material Events

DateEvent8-K
2026-08-05Earnings Release, Reg FD Disclosure…read
2026-06-18Officer / Director Change, Shareholder Vote…read
2026-05-05Earnings Release, Exhibitsread
2026-02-25Earnings Release, Exhibitsread
2026-01-12Reg FD Disclosure, Exhibitsread
2025-11-06Earnings Release, Exhibitsread
2025-08-06Earnings Release, Exhibitsread
2025-06-26Shareholder Voteread
2025-05-06Earnings Release, Exhibitsread
2025-03-20Other Material Eventread
2025-03-10Other Material Event, Exhibitsread
2025-03-03Other Material Event, Exhibitsread

Flow & Concentration

Insider 180d net$0
Insider buys / sells0 / 0
Insider biasNeutral
13F holders7
Top-5 share99.8%
HHI4,136 (concentrated)

Top Holders

HolderValueShares
Capital Research / Capital World$416.68M3.40M
State Street Corp$407.16M3.32M
Fidelity / FMR LLC$82.40M672.19K
Citadel Advisors$5.61M45.80K
AQR Capital Management$1.61M13.10K
Bridgewater Associates$1.14M9.27K
T. Rowe Price Group$263.51K2.15M

As of 2026-06-30

SEC Filings

DateFormDoc
2026-08-124view
2026-08-058-Kview
2026-08-0510-Qview
2026-06-254view
2026-06-188-Kview
2026-06-114view
2026-06-014view
2026-05-124view
2026-05-114view
2026-05-0510-Qview
2026-05-058-Kview
2026-04-28DEFA14Aview
2026-04-28ARSview
2026-04-28DEF 14Aview
2026-04-244view

The Long Run

FY 2016–2025 · 10 years

LineLatestCAGRTrend
Operating income-$158.13M—
Net income-$130.15M—
Cash from ops$57.67M—

Indices

S&P SmallCap 600

Recent Sessions

DateOpenHighLowCloseVol
Sep 25$141.81$143.45$138.23$141.86809.20K
Sep 24$138.76$140.80$134.10$137.34989.20K
Sep 23$144.27$145.28$137.88$138.70513.20K
Sep 22$144.64$147.71$144.50$145.07806.20K
Sep 21$143.22$145.37$141.09$144.98822.20K

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