Inside the research
Protagonist Therapeutics, Inc.
PTGX Research profile · latest available data
Price overview
$141.86
▲ +4.52 (+3.3%)
| 52w hi | $158.62 |
|---|---|
| 52w lo | $64.00 |
| Vol | 809.20K |
| As of | 25 Sep 2026 |
The Verdict
Our score +0.66
| Short | +0.59 |
|---|---|
| Medium | +0.75 |
| Long | +0.64 |
computed 2026-09-27
Key fundamentals
Protagonist Therapeutics, Inc.
Healthcare · Biotechnology
| Market cap | $9.18B |
|---|---|
| Enterprise value | $8.41B |
| Trailing P/E | 136.40x |
| Forward P/E | -712.33x |
| EV / EBITDA | 140.38x |
| P / S (ttm) | 32.55x |
| Profit margin | 29.4% |
| Return on equity | 11.0% |
| Revenue growth | +3749.2% |
| Debt / equity | 1.09 |
Layer Breakdown
| Layer | Raw | Contribution |
|---|---|---|
| Fundamental | +0.34 | |
| Sector | +0.08 | |
| Technical | +0.34 | |
| Earnings | +0.00 | |
| Sentiment | +0.22 |
macro × 1.00 · 2026-09-27
Business overview
Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.
Risk Metrics
| Beta vs SPX | 0.22 |
|---|---|
| Corr SPX | 0.06 |
| Annual vol | 56.8% |
| Annual ret | +69.4% |
| Sharpe | 1.22 |
| Max DD | -31.6% |
Window: 504 trading days (504 obs)
Material Events
| Date | Event | 8-K |
|---|---|---|
| 2026-08-05 | Earnings Release, Reg FD Disclosure… | read |
| 2026-06-18 | Officer / Director Change, Shareholder Vote… | read |
| 2026-05-05 | Earnings Release, Exhibits | read |
| 2026-02-25 | Earnings Release, Exhibits | read |
| 2026-01-12 | Reg FD Disclosure, Exhibits | read |
| 2025-11-06 | Earnings Release, Exhibits | read |
| 2025-08-06 | Earnings Release, Exhibits | read |
| 2025-06-26 | Shareholder Vote | read |
| 2025-05-06 | Earnings Release, Exhibits | read |
| 2025-03-20 | Other Material Event | read |
| 2025-03-10 | Other Material Event, Exhibits | read |
| 2025-03-03 | Other Material Event, Exhibits | read |
Flow & Concentration
| Insider 180d net | $0 |
|---|---|
| Insider buys / sells | 0 / 0 |
| Insider bias | Neutral |
| 13F holders | 7 |
| Top-5 share | 99.8% |
| HHI | 4,136 (concentrated) |
Top Holders
| Holder | Value | Shares |
|---|---|---|
| Capital Research / Capital World | $416.68M | 3.40M |
| State Street Corp | $407.16M | 3.32M |
| Fidelity / FMR LLC | $82.40M | 672.19K |
| Citadel Advisors | $5.61M | 45.80K |
| AQR Capital Management | $1.61M | 13.10K |
| Bridgewater Associates | $1.14M | 9.27K |
| T. Rowe Price Group | $263.51K | 2.15M |
As of 2026-06-30
SEC Filings
The Long Run
FY 2016–2025 · 10 years
| Line | Latest | CAGR | Trend |
|---|---|---|---|
| Operating income | -$158.13M | — | |
| Net income | -$130.15M | — | |
| Cash from ops | $57.67M | — |
Indices
Recent Sessions
| Date | Open | High | Low | Close | Vol |
|---|---|---|---|---|---|
| Sep 25 | $141.81 | $143.45 | $138.23 | $141.86 | 809.20K |
| Sep 24 | $138.76 | $140.80 | $134.10 | $137.34 | 989.20K |
| Sep 23 | $144.27 | $145.28 | $137.88 | $138.70 | 513.20K |
| Sep 22 | $144.64 | $147.71 | $144.50 | $145.07 | 806.20K |
| Sep 21 | $143.22 | $145.37 | $141.09 | $144.98 | 822.20K |
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