Subject of the day
PTGX
Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.
FY 2016–2025 · 10 years
| Line | Latest | CAGR | Trend |
|---|---|---|---|
| Operating income | -$158.13M | — | |
| Net income | -$130.15M | — | |
| Cash from ops | $57.67M | — |
$151.42
▼ -0.59 (-0.4%)
| 52w hi | $152.01 |
|---|---|
| 52w lo | $54.53 |
| Vol | 378.98K |
| As of | Aug 13 |
Our score +0.17
| Short | -0.12 |
|---|---|
| Medium | +0.28 |
| Long | +0.52 |
computed 2026-08-13
Protagonist Therapeutics, Inc.
Healthcare · Biotechnology
| Market cap | $9.80B |
|---|---|
| Enterprise value | $9.06B |
| Trailing P/E | 147.01x |
| Forward P/E | -1082.96x |
| EV / EBITDA | 151.34x |
| P / S (ttm) | 34.75x |
| Profit margin | 29.4% |
| Return on equity | 11.0% |
| Revenue growth | +3749.2% |
| Earnings growth | — |
| Debt / equity | 1.09 |
| Beta vs SPX | 0.25 |
|---|---|
| Corr SPX | 0.07 |
| Annual vol | 57.0% |
| Annual ret | +85.6% |
| Sharpe | 1.50 |
| Max DD | -31.6% |
Window: 504 trading days (504 obs)
| Layer | Raw | Contribution |
|---|---|---|
| Fundamental | +0.34 | |
| Sector | +0.12 | |
| Technical | +0.00 | |
| Earnings | +0.00 | |
| Sentiment | +0.00 |
macro × 1.00 · 2026-08-13
| Date | Open | High | Low | Close | Vol |
|---|---|---|---|---|---|
| Aug 13 | $153.15 | $154.99 | $150.92 | $151.42 | 378.98K |
| Aug 12 | $148.21 | $152.70 | $147.33 | $152.01 | 417.20K |
| Aug 11 | $151.88 | $151.88 | $147.37 | — | 306.10K |
| Aug 10 | $149.31 | $151.60 | $147.40 | $150.00 | 545.80K |
| Aug 7 | $146.18 | $147.32 | $144.44 | $145.87 | 321.10K |